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제목 [한국생체재료학회지] 제 23권 4호 167-195
작성자 관리자 등록일 2020-01-02
첨부파일

In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease
monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and
are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received
significant attention due to their versatility. Although enormous strides have been made in research and
development in the field of nanotechnology, it is often confusing for beginners to make an informed choice
regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to
briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization
would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based
nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the
biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery,
controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of
suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed.
Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the
biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate
straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges
associated with each drug delivery method.
Keywords: Nanoparticles, Nanocarriers, Drug delivery, Drug administration, Targeted drug delivery, Administration
route, Therapeutics, Cancer

 

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