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제목 [한국생체재료학회지] 제 21권 4호 157-164
작성자 관리자 등록일 2018-01-05
첨부파일

Background: An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing elastic modulus of the hydrogels because of decreased transport of ions through a polymeric cross-linked mesh. Method: This study hypothesized that the inverse dependency between electrical conductivity and elastic modulus would be made through the cross-linking of conductive monomer-units conjugated to a hydrophilic polymeric backbone. This hypothesis was examined through the cross-linking of pyrrole groups that were conjugated to an alginate backbone, termed alginate-g-pyrrole. Results: Hydrogels with increased degrees of pyrrole substitution exhibited a simultaneous increase in the gels mechanical rigidity and electrical conductivity. The resulting hydrogel could control the adhesion and vascular endothelial growth factor secretion of cells via applied electrical stimulation. Conclusions: This material design principle will be broadly useful to fabricating materials used for various actuation, cell culture, and biomedical applications.
 

Key words : Alginate hydrogel, Pyrrole, Electrical stimulation, Vascular endothelial growth factor, Elastic modulus

 

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