간행물열람

한국생체재료학회에 오신 것을 환영합니다.
home > 간행물 > 간행물열람
학회지 및 기타 간행물의 열람 제한
  • 홈페이지상에서 학회지 및 기타 간행물의 열람 및 다운로드가 가능합니다.
  • 이하의 게시물은 홈페이지의 실명으로 회원가입하신 후 학회회원임이 확인되신 경우 로그인 후 열람이 가능합니다. 궁금한 점은 생체재료학회 사무국(e-mail : ksbm2011@naver.com) 으로 문의하시기 바랍니다.
제목 [한국생체재료학회지] 제 21권 4호 137-143
작성자 관리자 등록일 2018-01-05
첨부파일

Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.
 

Key words : Aggregation induced emission, Polyion complex, Photodynamic therapy, Dendrimer, Polyoxazoline

 

[ 논문 다운로드]